Ishida & Asakura focuses on the title characters—the stoic Ishida and the lecherous Asakura—and the bizarre students and teachers that populate their high school. Asakura is obsessed with curvaceous women and dreams of becoming a teacher in order to be surrounded by attractive girls all day. Ishida dreams of running a flower shop together with Asakura after they finish high school, and appears to have strong homosexual feelings for his best friend, although this is always played for laughs.

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