Spider-Man: Return of the Sinister Six is a video game featuring the Marvel Comics characters Spider-Man and the Sinister Six, developed by Bits Studios and published by LJN for the Nintendo Entertainment System in 1992. Versions of the game were also released for the Sega Master System and Game Gear by the Flying Edge division of Acclaim. The game is loosely based on the story arc of the same name, which was published in The Amazing Spider-Man #334-339 in the early 1990s.

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